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. 2021 Sep 15;12:707399. doi: 10.3389/fphar.2021.707399

FIGURE 1.

FIGURE 1

Trimetazidine ameliorated pressure overload-induced heart failure. (A) Representative M-mode echocardiograms after transverse aortic constriction (TAC) or trimetazidine (TMZ) treatment. (B) Diastole for left ventricular internal diameter (LVIDd). (C) Left ventricular ejection fraction (EF). (D) Representative histological images of H&E (scale bar = 100 um) and wheat germ agglutinin (WGA) staining (scale bar = 100 um). (F) Left ventricular weight (LVW) to tibia length (TL) ratio. (E) Relative across sectional area (CSA) of cardiomyocytes calculated from WGA staining. (G) Representative cardiac section stained with Masson’s trichrome (scale bar = 100 um). (H,I) Quantitative results of perivascular fibrosis area (PVF) and myocardial fibrosis area (MFA). Graphical data are shown as mean ± SEM. One-way ANOVA was used for analysis. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, vs indicated group.