FIGURE 2.

Trimetazidine improved the pressure overload-induced impairment of mitochondrial structure and function. (A) Representative ultrastructure image of mitochondria of mice heart (zoomed scale bar = 0.5 um). (B) Cardiac ATP content. (C–F) Representative western blots of mitochondrial dynamic protein and corresponding quantitative results. Four samples were included, Graphical data are shown as mean ± SEM. Two-way ANOVA was used for analysis. *p < 0.05, ****p < 0.0001 vs indicated group. TAC, Transverse aortic constriction; TMZ, Trimetazidine.