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. 2021 Sep 15;12:707399. doi: 10.3389/fphar.2021.707399

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Copyright © 2021 Shu, Hang, Peng, Nie, Wu, Zhang, Wang and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Trimetazidine attenuated the cardiac insulin resistance evoked by pressure overload. (A) Representative PET images showing the glucose uptake rate of mice heart, and corresponding calculated results (B,C) n = 3. (D) Glucose uptake rate of isolated adult cardiomyocytes by 2-NBDG assay, n = 3. (E) Immunofluorescence staining images labeling GLUT4 (red) and DAPI (blue) in mice heart tissue. Scale bar = 50 um. (F) Representative western blots of GLUT4 in membrane and cytoplasm in indicated groups, GAPDH was used as cytoplasm loading control and the total protein control, Na-K-ATPase was used as membrane loading control. (G,H) The protein levels of InsR, Akt and their phosphorylation states, n = 6. Graphical data are shown as mean ± SEM. Two-way ANOVA was used for analysis. *p < 0.05, **p < 0.01, ***p < 0.001 vs indicated group. TAC, Transverse aortic constriction; TMZ, Trimetazidine; SUV, Standard uptake value.