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. 2021 Sep 15;12:707399. doi: 10.3389/fphar.2021.707399

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Copyright © 2021 Shu, Hang, Peng, Nie, Wu, Zhang, Wang and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AMPK was essential for the attenuation of pressure overload-induced mitochondria dysfunction, cardiac insulin resistance and heart failure by the treatment of trimetazidine. (A,B) Representative western blots in mice heart and correspondence quantitative analysis. (C,D) Representative western blots in NRCMs and correspondence quantitative analysis. (E,F) Representative TEM of mice hearts and NRCM in indicated groups. Scale bar = 0.5 um. (G) The representative PET showing the cardiac glucose uptake and the quantitative analysis (H,I), n = 3. (J) Glucose uptake rate of isolated adult cardiomyocytes by 2-NBDG uptake assay, n = 3. Graphical data are shown as mean ± SEM. Two-way ANOVA was used for analysis. *p < 0.05, **p < 0.01, ****p < 0.0001, vs indicated group. TAC, Transverse aortic constriction; MS, Mechanical stretch; C.C., Compound C; SUV, Standard uptake value.