Table 2.
Efficacy and Safety Analyses for All Patients.
| All patients (n=126) | Baseline | Week 24 | p value | |||
|---|---|---|---|---|---|---|
| Efficacy parameters | ||||||
| TC (mg/dL) | 192.0 [163.5, 222.0] | 173.0 [144.3, 204.0] | <0.001 | |||
| LDL-C (mg/dL) | 105.0 [82.8, 129.5] | 95.0 [72.5, 119.0] | 0.025 | |||
| non-HDL-C (mg/dL) | 146.0 [119.0, 178.0] | 121.0 [94.0, 148.0] | <0.001 | |||
| TG (mg/dL) | 269.0 [180.0, 423.8] | 161.0 [107.0, 227.3] | <0.001 | |||
| HDL-C (mg/dL) | 44.0 [36.8, 53.0] | 51.0 [43.0, 59.0] | 0.001 | |||
| Safety parameters | ||||||
| BUN (mg/dL) | 16.0 [13.0, 20.0] | 16.6 [13.0, 20.0] | 0.821 | |||
| Cre (mg/dL) | 0.87 [0.69, 1.04] | 0.84 [0.70, 1.10] | 0.996 | |||
| eGFR (mL/min/1.73m2) | 62.1 [50.9, 74.9] | 64.2 [49.5, 78.5] | 0.965 | |||
| ALT (IU/L) | 26.0 [17.8, 37.0] | 17.5 [14.0, 27.0] | 0.001 | |||
| γGT (IU/L) | 40.5 [26.3, 68.8] | 29.5 [18.0, 50.8] | 0.07 | |||
| CK (U/L) | 81.0 [66.0, 112.5] | 76.0 [56.0, 102.0] | 0.088 |
Data are presented as the median [25%, 75%]. p<0.05 vs. baseline value by Mann-Whitney U test.
TC: total cholesterol, LDL-C: low-density lipoprotein cholesterol, non-HDL-C: non-high-density lipoprotein cholesterol, TG: triglycerides, HDL-C: high-density lipoprotein cholesterol, BUN: blood urea nitrogen, Cre: creatinine, eGFR: estimated glomerular filtration rate, ALT: alanine aminotransferase, γGT: γ-glutamyl transferase, CK: creatine kinase