Table 5.
Efficacy and Safety Analyses for the Group of Patients with Chronic Kidney Disease (CKD Group).
| CKD group (n=54) | Baseline | Week 24 | p value | |||
|---|---|---|---|---|---|---|
| Efficacy parameters | ||||||
| TC (mg/dL) | 184.5 [161.5, 221.5] | 165.0 [138.8, 187.5] | <0.001 | |||
| LDL-C (mg/dL) | 96.5 [74.5, 129.0] | 94.0 [71.0, 108.0] | 0.055 | |||
| non-HDL-C (mg/dL) | 144.5 [116.0, 175.8] | 115.0 [93.0, 137.5] | <0.001 | |||
| TG (mg/dL) | 260.0 [200.8, 383.0] | 167.0 [112.0, 221.0] | 0.002 | |||
| HDL-C (mg/dL) | 42.5 [35.0, 48.0] | 48.0 [39.3, 53.8] | 0.26 | |||
| Safety parameters | ||||||
| BUN (mg/dL) | 19.0 [16.0, 23.6] | 18.4 [15.2, 22.1] | 0.761 | |||
| Cre (mg/dL) | 1.07 [0.94, 1.29] | 1.11 [0.86, 1.33] | 0.853 | |||
| eGFR (mL/min/1.73m2) | 47.6 [41.7, 55.8] | 48.0 [40.4, 59.1] | 0.6 | |||
| ALT (IU/L) | 23.0 [17.0, 35.3] | 18.0 [14.0, 27.0] | 0.098 | |||
| γGT (IU/L) | 41.5 [24.3, 52.5] | 25.0 [17.8, 42.3] | 0.698 | |||
| CK (U/L) | 79.0 [59.5, 101.0] | 76.0 [56.0, 98.0] | 0.486 |
Data are presented as the median [25%, 75%]. p<0.05 vs. baseline value by Mann-Whitney U test.
TC: total cholesterol, LDL-C: low-density lipoprotein cholesterol, non-HDL-C: non-high-density lipoprotein cholesterol, TG: triglycerides, HDL-C: high-density lipoprotein cholesterol, BUN: blood urea nitrogen, Cre: creatinine, eGFR: estimated glomerular filtration rate, ALT: alanine aminotransferase, γGT: γ-glutamyl transferase, CK: creatine kinase