Table 6.
Efficacy and Safety Analyses for the Group of Patients without Chronic Kidney Disease (non-CKD Group).
| non-CKD group (n=72) | Baseline | Week 24 | p value | |||
|---|---|---|---|---|---|---|
| Efficacy parameters | ||||||
| TC (mg/dL) | 199.5 [164.3, 222.0] | 179.0 [147.0, 209.5] | 0.013 | |||
| LDL-C (mg/dL) | 109.5 [86.3, 131.0] | 96.0 [75.3, 123.8] | 0.174 | |||
| non-HDL-C (mg/dL) | 152.5 [121.0, 178.8] | 128.0 [94.8, 152.8] | 0.001 | |||
| TG (mg/dL) | 273.0 [155.5, 525.5] | 154.0 [87.3, 242.3] | 0.001 | |||
| HDL-C (mg/dL) | 46.0 [37.3, 53.0] | 52.0 [44.3, 62.0] | 0.008 | |||
| Safety parameters | ||||||
| BUN (mg/dL) | 14.4 [11.0, 18.0] | 15.0 [12.0, 18.0] | 0.396 | |||
| Cre (mg/dL) | 0.74 [0.62, 0.89] | 0.75 [0.65, 0.86] | 0.648 | |||
| eGFR (mL/min/1.73m2) | 73.5 [66.3, 86.3] | 76.9 [65.1, 81.3] | 0.591 | |||
| ALT (IU/L) | 27.0 [18.3, 40.5] | 17.0 [13.0, 26.8] | 0.003 | |||
| γGT (IU/L) | 41.0 [29.0, 82.0] | 32.0 [18.0, 52.0] | 0.01 | |||
| CK (U/L) | 85.5 [68.0, 114.0] | 78.5 [56.0, 104.5] | 0.071 |
Data are presented as the median [25%, 75%]. p<0.05 vs. baseline value by Mann-Whitney U test.
TC: total cholesterol, LDL-C: low-density lipoprotein cholesterol, non-HDL-C: non-high-density lipoprotein cholesterol, TG: triglycerides, HDL-C: high-density lipoprotein cholesterol, BUN: blood urea nitrogen, Cre: creatinine, eGFR: estimated glomerular filtration rate, ALT: alanine aminotransferase, γGT: γ-glutamyl transferase, CK: creatine kinase