Table 2.
21 differentially altered metabolites in serum samples measured by mass spectrometry comparing all groups. Abbreviations; AD: Alzheimer's Disease, ANOVA: analysis of variance, Con: healthy controls, FC: fold change, FDR: false discovery rate, MCI: Mild Cognitive Impairment.
| Metabolites |
Mean ± SD [Intensities] |
ANOVA | FDR |
AD |Con |
MCI |Con |
AD |MCI |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Con | MCI | AD | FC | p | FC | p | FC | p | |||
| 1-Pentadecanoyl-sn-glycero-3-phosphocholine | 970.2 ± 282.5 | 1249.8 ± 478.9 | 507.9 ± 210.0 | 0.0004 | 0.020 | 0.5 | 0.021 | 1.3 | 0.213 | 0.4 | 0.0003 |
| Allopurinol riboside | 1829.6 ± 1293.6 | 296.5 ± 193.8 | 444.4 ± 330.8 | 0.0004 | 0.020 | 0.2 | 0.002 | 0.2 | 0.001 | 1.5 | 0.915 |
| Inosine | 1626.3 ± 1014.0 | 404.7 ± 258.1 | 496.4 ± 361.9 | 0.0005 | 0.020 | 0.3 | 0.002 | 0.2 | 0.001 | 1.2 | 0.950 |
| Guanosine | 1809.1 ± 1069.5 | 401.2 ± 387.7 | 590.5 ± 556.7 | 0.0006 | 0.020 | 0.3 | 0.004 | 0.2 | 0.001 | 1.5 | 0.848 |
| 1-Palmitoyl-sn-glycero-3-phosphocholine | 997.1 ± 246.8 | 1109.8 ± 283.7 | 625.4 ± 222.1 | 0.001 | 0.025 | 0.6 | 0.011 | 1.1 | 0.615 | 0.6 | 0.001 |
| 13-cis-Retinol | 876.4 ± 207.2 | 1244.9 ± 467.0 | 590.3 ± 293.7 | 0.001 | 0.032 | 0.7 | 0.194 | 1.4 | 0.073 | 0.5 | 0.001 |
| 4-Pyridoxic acid | 815.4 ± 119.9 | 1234.5 ± 309.8 | 1288.6 ± 393.5 | 0.004 | 0.074 | 1.6 | 0.006 | 1.5 | 0.016 | 1.0 | 0.921 |
| 1-Myristoyl-sn-glycero-3-phosphocholine | 1170.2 ± 527.6 | 1198.8 ± 534.9 | 548.9 ± 271.9 | 0.009 | 0.139 | 0.5 | 0.021 | 1.0 | 0.991 | 0.5 | 0.016 |
| 2-Isopropylmalic acid | 769.4 ± 209.3 | 1164.1 ± 319.1 | 1135.1 ± 311.0 | 0.011 | 0.147 | 1.5 | 0.029 | 1.5 | 0.017 | 1.0 | 0.974 |
| Leu-Leu | 842.5 ± 223.6 | 946.4 ± 319.7 | 1366.4 ± 488.3 | 0.011 | 0.147 | 1.6 | 0.013 | 1.1 | 0.816 | 1.4 | 0.051 |
| 7-Methylguanine | 1021.0 ± 141.6 | 1040.4 ± 165.1 | 1308.5 ± 298.9 | 0.013 | 0.156 | 1.3 | 0.021 | 1.0 | 0.980 | 1.3 | 0.033 |
| 2-Phenylethanol,sulfate | 724.1 ± 390.3 | 845.6 ± 503.7 | 1570.6 ± 882.6 | 0.017 | 0.164 | 2.2 | 0.021 | 1.2 | 0.912 | 1.9 | 0.054 |
| 1-Oleoyl-sn-glycero-3-phosphocholine | 971.3 ± 289.9 | 1070.1 ± 270.7 | 674.4 ± 289.6 | 0.017 | 0.164 | 0.7 | 0.086 | 1.1 | 0.742 | 0.6 | 0.017 |
| l-Lysine | 1138.1 ± 312.3 | 795.2 ± 150.8 | 1085.9 ± 280.5 | 0.019 | 0.164 | 1.0 | 0.904 | 0.7 | 0.023 | 1.4 | 0.060 |
| 5-Androsten-3β,17β-diol-3-sulfate | 777.0 ± 490.1 | 696.2 ± 513.6 | 1478.9 ± 775.1 | 0.020 | 0.164 | 1.9 | 0.053 | 0.9 | 0.957 | 2.1 | 0.028 |
| 1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine | 892.4 ± 397.8 | 1094.5 ± 336.2 | 633.7 ± 217.4 | 0.020 | 0.164 | 0.7 | 0.230 | 1.2 | 0.399 | 0.6 | 0.015 |
| 9(10)-Epoxy-12Z-octadecenoic acid | 694.8 ± 412.9 | 1342.5 ± 685.4 | 768.1 ± 379.0 | 0.023 | 0.179 | 1.1 | 0.950 | 1.9 | 0.032 | 0.6 | 0.061 |
| 3-Methylglutarylcarnitine | 600.8 ± 190.9 | 995.2 ± 420.7 | 1214.7 ± 695.4 | 0.037 | 0.251 | 2.0 | 0.031 | 1.7 | 0.211 | 1.2 | 0.604 |
| D-erythro-Sphingosine-1-phosphate | 905.0 ± 247.9 | 1156.4 ± 454.3 | 732.4 ± 255.8 | 0.039 | 0.251 | 0.8 | 0.523 | 1.3 | 0.263 | 0.6 | 0.031 |
| Glycodeoxycholic acid | 1370.1 ± 869.5 | 837.6 ± 691.7 | 527.0 ± 314.6 | 0.039 | 0.251 | 0.4 | 0.032 | 0.6 | 0.226 | 0.6 | 0.590 |
| Lys-Trp | 827.9 ± 106.5 | 736.1 ± 47.4 | 774.3 ± 47.9 | 0.041 | 0.251 | 0.9 | 0.278 | 0.9 | 0.032 | 1.1 | 0.515 |