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. 2021 Jul 8;12(4):1373–1389. doi: 10.1016/j.jcmgh.2021.06.017

Figure 7.

Figure 7

E faecalis OG1RF_11616 causes worse colitis and decreased abundance of Bacteroides species. (A) Relative abundance of bacterial strains in cecal contents from Il10-/- mice colonized with the bacterial strains as in Figure 1 containing either parental E faecalis OG1RF or OG1RF_11616-deficient E faecalis OG1RF (OG1RFΔ11616) for 8 weeks. (B) Composite histologic colitis scores in WT and Il10-/- mice colonized with the bacterial strains as in panel A for 4 and 8 weeks. (C) IL12/23p40 secretion by colon explant cultures from the same mice as in panel B (n = 4–6 mice/group, data presented as means ± SD, ∗P < .05 Mix+OG1RF vs Mix+OG1RFΔ11616, Student t test). nd, not detected.