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. 2021 Jul 8;12(4):1373–1389. doi: 10.1016/j.jcmgh.2021.06.017

Figure 8.

Figure 8

E faecalis OG1RF_11616-associated worsening of colitis requires complex microbiota. (A–C) Composite histologic colitis scores, spontaneous IL12/23p40 secretion by colon explant cultures, and E faecalis concentrations in cecal contents from Il10-/- mice monocolonized with E faecalis OG1RF or E faecalis OG1RFΔ11616 for 10 and 20 weeks (n = 5–6 mice/group, data presented as means ± SD, no differences between the 2 groups were statistically significant). (D–F) Composite histologic colitis scores, spontaneous IL2/23p40 secretion by colon explant cultures, and E faecalis concentrations in cecal contents from Il10-/- mice colonized with 5 bacterial strains (R gnavus, E coli, L rhamnosus, F prausnitzii, and B longum) and either E faecalis OG1RF or E faecalis OG1RFΔ11616 for 10 weeks (n = 7–9 mice/group, data presented as means ± SD, no differences between 2 groups were statistically significant). (G–I) Composite histologic colitis scores, spontaneous IL12/23p40 secretion by colon explant cultures, and E faecalis concentrations in cecal contents from Il10-/- mice colonized with B thetaiotaomicron (Bt), B vulgatus (Bv), and either E faecalis OG1RF or E faecalis OG1RFΔ11616 for 10 weeks (n = 6–7 mice/group, data presented as means ± SD, no differences between 2 groups were statistically significant). CFU, colony-forming unit.