Table 6.
Top 10 terms with the largest significant differences in the GO biological process analysis of DE mRNAs
| Term | Count | Rich ratio | p value | Candidate gene |
|---|---|---|---|---|
| Extracellular matrix organization | 25 | 0.090909 | 2.24E-11 | OLFML2B, NDNF, MMP11, OLFML2A, COL16A1, RECK, ADAM19, ITGA10, TNC, FBLN1, FGF2, MMP9, SERPINE1, COL5A3, EVI2A, TGFBI, THBS1, MFAP2, COMP, ERO1A, TNFRSF11B, COL14A1, KAZALD1, ABI3BP, COL4A1 |
| Ossification | 15 | 0.12605 | 2.79E-09 | TMEM119, LRRC17, IFITM1, MMP9, STC1, ACP5, MMP16, TWIST1, CLEC3B, PTN, COMP, RUNX2, KAZALD1, MGP, IGF2 |
| Cell adhesion | 38 | 0.048906 | 1.46E-08 | COL16A1, TINAGL1, S1PR1, RGMB, NRP2, PVR, ITGA10, TNC, EGFL7, JUP, THBS2, LOXL2, SCN1B, COL5A3, TGFBI, THBS1, MTSS1, PCDHGC3, CDH6, SPON2, BCAM, CXCL12, RND3, PERP, PCDHGB7, THBS3, COMP, CGREF1, PCDHGA10, COL14A1, CADM1, NRCAM, WISP2, SELENOP, MFAP4, GPNMB, EPHA2, PTPRU |
| Collagen fibril organization | 11 | 0.161765 | 2.64E-08 | MMP11, GREM1, PLOD2, LOXL2, COL5A3, EVI2A, LOX, COMP, COL14A1, LOXL4, P4HA1 |
| Nucleosome assembly | 15 | 0.088757 | 3.21E-07 | SMYD3, HIST1H4F, HIST1H1B, HIST1H4E, HIST1H2BI, HIST2H3D, HIST1H2BO, HIST1H4J, HIST1H4L, HIST1H4K, HIST1H4A, HIST1H3I, HIST1H3H, HIST1H3A, HIST1H2BN |
| Angiogenesis | 21 | 0.058496 | 1.73E-06 | LEP, NDNF, GREM1, ANGPTL4, S1PR1, NRP2, SLC38A1, EPGN, CXCL8, EPHB2, EGFL7, ADGRA2, SERPINE1, JAG1, TGFBI, FZD8, CAV1, CCBE1, NRCAM, EPHA2, COL4A1 |
| Cellular response to hypoxia | 13 | 0.089655 | 1.75E-06 | NDNF, MGARP, ANKRD1, STC1, TWIST1, FMN2, STC2, EDN1, PTN, NOP53, ZFP36L1, BNIP3, ERO1A |
| Skeletal system development | 14 | 0.075676 | 5.25E-06 | SH3PXD2B, FAM20C, NPR3, SOX4, PAPSS2, MMP9, ANKH, EDN1, AEBP1, COMP, RUNX2, TNFRSF11B, EPHA2, IGF2 |
| Negative regulation of blood coagulation | 5 | 0.294118 | 8.40E-06 | APOE, TFPI, SERPINE1, EDN1, SERPINE2 |
| Amino acid transport | 8 | 0.131148 | 1.09E-05 | SLC7A11, SLC38A1, SLC1A1, SLC7A14, SLC7A8, SLC38A5, PDPN, SLC43A1 |