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. 2021 Aug 19;26:557–574. doi: 10.1016/j.omtn.2021.08.013

Table 7.

Top 10 biological pathways with the largest significant differences in the KEGG pathway analysis of DE mRNAs

Pathway Count Rich ratio p value Gene
Systemic lupus erythematosus 21 0.094595 2.77E−10 HIST1H4F, HIST1H4E, HIST1H2BI, HIST2H3D, HIST2H2AB, HIST1H2AH, HIST1H2BO, HIST1H4J, HIST1H4L, C1S, HIST1H4K, HIST1H4A, HIST2H2AC, HIST1H2AB, C1R, HIST1H3I, 105369230, HIST1H3H, HIST1H2AM, HIST1H3A, HIST1H2BN
Alcoholism 20 0.096154 5.59E−10 BDNF, HIST1H4F, HIST1H4E, HIST1H2BI, HIST2H3D, HIST2H2AB, HIST1H2AH, HIST1H2BO, HIST1H4J, HIST1H4L, HIST1H4K, SHC2, HIST1H4A, HIST2H2AC, HIST1H2AB, HIST1H3I, HIST1H3H, HIST1H2AM, HIST1H3A, HIST1H2BN
Malaria 7 0.102941 1.67E−04 CXCL8, THBS2, THBS1, GYPC, THBS3, COMP, SDC1
Complement and coagulation cascades 9 0.076271 2.07E−04 CLU, TFPI, SERPINE1, C1S, C1R, CD55, CFI, SERPINB2, CFB
ECM-receptor interaction 8 0.063492 0.001548 ITGA10, TNC, THBS2, THBS1, THBS3, COMP, SDC1, COL4A1
Wnt signaling pathway 10 0.052632 0.001745 GREM1, PLCB4, CCND1, FZD8, DKK1, DVL2, PORCN, SERPINF1, CCND2, SFRP4
AGE-RAGE signaling pathway in diabetic complications 8 0.061069 0.00198 STAT5A, PLCB4, CXCL8, CCND1, SERPINE1, EDN1, STAT1, COL4A1
Pathways in cancer 24 0.032742 0.002047 NOTCH3, DAPK2, STAT5A, SULF2, PLCB4, CXCL8, JUP, FGF2, MMP9, FGF5, CCND1, GLI3, JAG1, FZD8, GSTM4, STAT1, CXCL12, DVL2, SLC2A1, TXNRD1, ABI3BP, IGF2, COL4A1, CCND2
Protein digestion and absorption 7 0.066667 0.002287 COL16A1, SLC1A1, COL5A3, SLC7A8, COL14A1, VWCE, COL4A1
Bladder cancer 5 0.089286 0.002755 DAPK2, CXCL8, MMP9, CCND1, THBS1