Table 7.
Top 10 biological pathways with the largest significant differences in the KEGG pathway analysis of DE mRNAs
| Pathway | Count | Rich ratio | p value | Gene |
|---|---|---|---|---|
| Systemic lupus erythematosus | 21 | 0.094595 | 2.77E−10 | HIST1H4F, HIST1H4E, HIST1H2BI, HIST2H3D, HIST2H2AB, HIST1H2AH, HIST1H2BO, HIST1H4J, HIST1H4L, C1S, HIST1H4K, HIST1H4A, HIST2H2AC, HIST1H2AB, C1R, HIST1H3I, 105369230, HIST1H3H, HIST1H2AM, HIST1H3A, HIST1H2BN |
| Alcoholism | 20 | 0.096154 | 5.59E−10 | BDNF, HIST1H4F, HIST1H4E, HIST1H2BI, HIST2H3D, HIST2H2AB, HIST1H2AH, HIST1H2BO, HIST1H4J, HIST1H4L, HIST1H4K, SHC2, HIST1H4A, HIST2H2AC, HIST1H2AB, HIST1H3I, HIST1H3H, HIST1H2AM, HIST1H3A, HIST1H2BN |
| Malaria | 7 | 0.102941 | 1.67E−04 | CXCL8, THBS2, THBS1, GYPC, THBS3, COMP, SDC1 |
| Complement and coagulation cascades | 9 | 0.076271 | 2.07E−04 | CLU, TFPI, SERPINE1, C1S, C1R, CD55, CFI, SERPINB2, CFB |
| ECM-receptor interaction | 8 | 0.063492 | 0.001548 | ITGA10, TNC, THBS2, THBS1, THBS3, COMP, SDC1, COL4A1 |
| Wnt signaling pathway | 10 | 0.052632 | 0.001745 | GREM1, PLCB4, CCND1, FZD8, DKK1, DVL2, PORCN, SERPINF1, CCND2, SFRP4 |
| AGE-RAGE signaling pathway in diabetic complications | 8 | 0.061069 | 0.00198 | STAT5A, PLCB4, CXCL8, CCND1, SERPINE1, EDN1, STAT1, COL4A1 |
| Pathways in cancer | 24 | 0.032742 | 0.002047 | NOTCH3, DAPK2, STAT5A, SULF2, PLCB4, CXCL8, JUP, FGF2, MMP9, FGF5, CCND1, GLI3, JAG1, FZD8, GSTM4, STAT1, CXCL12, DVL2, SLC2A1, TXNRD1, ABI3BP, IGF2, COL4A1, CCND2 |
| Protein digestion and absorption | 7 | 0.066667 | 0.002287 | COL16A1, SLC1A1, COL5A3, SLC7A8, COL14A1, VWCE, COL4A1 |
| Bladder cancer | 5 | 0.089286 | 0.002755 | DAPK2, CXCL8, MMP9, CCND1, THBS1 |