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. 2021 Sep 28;2(10):100420. doi: 10.1016/j.xcrm.2021.100420

Figure 4.

Figure 4

Viral loads in the BAL fluid and Nasal swabs after viral challenge

At week 17, naive and INO-4800-immunized (5 per group) rhesus macaques were challenged by intranasal and intratracheal administration of 1.1 × 104 PFU SARS-CoV-2 (US-WA1 isolate).

(A) Log sgmRNA copies/mL in BAL in naive (left panel) and INO-4800-vaccinated animals (right panel).

(B and C) Peak sgmRNA (B) and viral RNA (C) in BAL 7 days post-challenge.

(D) Log sgmRNA copies/mL in nasal swabs in naive (left panel) and INO-4800-vaccinated animals (right panel).

(E and F) Peak sgmRNA (E) and viral RNA (F) in nasal swabs 7 days post-challenge. Black and blue lines represent median values.