Table 7.
Multinomial univariate logistic regressions: Impact of imaging features on relative odds of molecular subtypes
|
Luminal A baseline
|
Luminal B baseline
|
DCIS baseline
|
HER2 enriched baseline
|
TNBC baseline
|
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|
|
|
|
P
value
|
OR
|
95%CI
|
P
value
|
OR
|
95%CI
|
P
value
|
OR
|
95%CI
|
P
value
|
OR
|
95%CI
|
P
value
|
OR
|
95%CI
|
| Posterior acoustic features | Shadowing | Luminal A vs | d | 3.27 | (0.832 12.83) | b | 7.35 | (1.979 27.300) | |||||||||
| Luminal B vs | a | 7.50 | (1.307 43.030) | ||||||||||||||
| DCIS vs | d | 0.31 | (0.078 1.202) | ||||||||||||||
| HER2+ vs | b | 0.14 | (0.037 0.505) | a | 0.13 | (0.023 0.765) | |||||||||||
| TNBC vs | |||||||||||||||||
| Enhancement | Luminal A vs | b | 0.19 | (0.055 0.633) | |||||||||||||
| Luminal B vs | |||||||||||||||||
| DCIS vs | a | 0.12 | (0.024 0.610) | ||||||||||||||
| HER2+ vs | a | 0.22 | (0.058 0.807) | ||||||||||||||
| TNBC vs | b | 5.38 | (1.581 18.310) | a | 8.25 | (1.638 41.55) | a | 4.64 | (1.239 17.38) | ||||||||
| Margins (on US) | Spiculated | Luminal A vs | a | 2.45 | (1.130 5.31) | b | 5.41 | (1.931 15.14) | c | 5.88 | (2.544 13.58) | c | 4.26 | (1.805 10.056) | |||
| Luminal B vs | a | 0.41 | (0.188 0.885) | d | 2.40 | (0.861 6.690) | |||||||||||
| DCIS vs | b | 0.19 | (0.066 0.518) | ||||||||||||||
| HER2+ vs | c | 0.17 | (0.074 0.393) | d | 0.42 | (0.150 1.16) | |||||||||||
| TNBC vs | c | 0.24 | (0.099 0.554) | ||||||||||||||
| Circumscribed | Luminal A vs | b | 0.09 | (0.019 0.445) | |||||||||||||
| Luminal B vs | |||||||||||||||||
| DCIS vs | |||||||||||||||||
| HER2+ vs | |||||||||||||||||
| TNBC vs | b | 10.8 | (2.246 52.043) | ||||||||||||||
| Size | Large | Luminal A vs | a | 0.51 | (0.258 0.999) | c | 0.07 | (0.024 0.208) | |||||||||
| Luminal B vs | c | 0.08 | (0.023 0.259) | ||||||||||||||
| DCIS vs | c | 0.04 | (0.010 0.134) | ||||||||||||||
| HER2+ vs | a | 1.97 | (1.001 3.878) | c | 0.14 | (0.043 0.450) | |||||||||||
| TNBC vs | c | 14.20 | (4.811 41.915) | c | 12.94 | (3.856 43.427) | c | 26.89 | (7.445 97.114) | c | 7.21 | (2.224 23.354) | |||||
| High-risk Microcals | Present | Luminal A vs | c | 0.30 | (0.154 0.583) | b | 0.34 | (0.171 0.665) | |||||||||
| Luminal B vs | d | 0.44 | (0.186 1.061) | ||||||||||||||
| DCIS vs | c | 3.34 | (1.715 6.488) | d | 2.25 | (0.942 5.37) | b | 4.50 | (1.606 9.96) | ||||||||
| HER2+ vs | b | 2.97 | (1.504 5.844) | b | 4.00 | (1.824 11.10) | |||||||||||
| TNBC vs | b | 0.22 | (0.090 0.548) | 0.25 | (0.100 0.623) | ||||||||||||
| Adler | High | Luminal A vs | c | 0.27 | (0.131 0.566) | b | 0.30 | (0.142 0.618) | |||||||||
| Luminal B vs | |||||||||||||||||
| DCIS vs | d | 0.38 | (0.136 1.037) | d | 0.41 | (0.147 1.131) | |||||||||||
| HER2+ vs | c | 3.68 | (1.767 7.650) | d | 2.67 | (0.965 7.37) | |||||||||||
| TNBC vs | b | 3.38 | (1.618 7.045) | d | 2.45 | (0.884 6.78) | |||||||||||
| Axillary node adenopathy | Yes | Luminal A vs | a | 3.08 | (1.063 61.96) | a | 0.44 | (0.209 0.919) | |||||||||
| Luminal B vs | a | 0.12 | (0.224 0.470) | a | 0.07 | (0.009 0.556) | b | 0.05 | (0.007 0.430) | ||||||||
| DCIS vs | |||||||||||||||||
| HER2+ vs | a | 14.40 | (1.798 115.17) | ||||||||||||||
| TNBC vs | a | 2.28 | (1.088 4.778) | b | 18.50 | (2.323 147.34) | |||||||||||
a
Significant at the 0.001 level.
b
Significant at the 0.01 level.
c
Significant at the 0.05 level.
d
Significant at the 0.10 level.
Only statistically significant results are shown. Bold results show higher relative odds. DCIS: Ductal carcinoma in situ; TNBC: Triple-negative breast cancer; US: Ultrasound.