Figure 1.

(a) Plot showing BLAST determined dog chromosome 5 locations of 486 SNPs significant in GWAS of fur colour in Arctic fox. The horizontal lines above the x-axis and the corresponding numbers show how the different Arctic fox scaffolds BLAST to dog chromosome 5. On the y-axis, significance levels of the SNPs in the GWAS are shown on a negative log scale. Pairwise LD (r²) between top SNP AX177333963 and the other significant SNPs is shown by the blue colour gradient. All dog genes in the region are shown as grey lines at the top. The position of putative causal gene MC1R is shown with an orange dot (note that the y-axis values do not apply for genes). The dashed horizontal line shows the significance threshold after Bonferroni correction of the GWAS. (b) Predicted fitness (lambda) of the Arctic fox fur colour morph genotypes CC (white) and TC (blue). Whiskers represent 95% confidence intervals of predicted values. Predictions are based on additive GLMMs with genotype as predictor variable and year and subpopulation as random factors. (Online version in colour.)