Table 1.
Amino acid changes identified in the B.1.575 viral genome sequences obtained from a cat, dog, and pet owner living in the same household, and two related SARS-CoV-2 positive human specimens in Arizona. The bolded mutationsa – L18F and Q613H – are unique to these five genomes.
| Sample Name | SARS- CoV-2 Protein Names |
||||
|---|---|---|---|---|---|
| ORF1a | ORF1b | S | N | M | |
| EPI ISL 1525089 (Cat) TGen-CoV-AZ (Dog) EPI ISL 1464779 (Owner) EPI ISL 1525972 EPI ISL 1363573 |
Q57H, T492I, T85I, T181I | P47S, P323L | L18F, S494P, Q613H, D614G, T716I, P681H | T205I | I82T |
a
The L18F and Q613H mutations have been found in approximately 1% of all genomes of the B.1.575 lineage. The L18F mutation has been associated with several variants of concern and may play a role in viral transmission and immune evasion [18]. The Q613H mutation occurs in the ACE-2 receptor binding domain of the spike protein.