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ASGR1 specificity for LDLR. HepG2-PCSK9-KO cells were transfected with 20 nM nontargeting (Cnt) siRNA or siRNA ASGR1 for 48 h. Western blot analyses and quantification of total cellular LDLR, ASGR1, CD36, and IR-β from three independent experiments are shown. Quantifications are averages ±SD. ∗∗∗p < 0.001 (t test).
