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LDLR and ASGR1 expression levels in livers from wildtype (WT) mice and mice lacking mPCSK9 (PCSK9-KO) or mLDLR (Ldlr-KO), respectively.A, LDLR and ASGR1 staining by immunohistochemistry (green signal) in mouse liver sections. B, Western blot analysis of total ASGR1 and LDLR proteins in mouse livers. Data are representative of 9 to 10 mice (A) and 3 to 4 mice (B), and quantifications are averages ±SD. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001 (t test).
