Fig. 5.

Burden of ultra-rare variants in groups of epilepsy-related known disease genes. The burden in five gene-sets (y-axis; number of genes in parenthesis) in developmental and epileptic encephalopathies (DEE), genetic generalized epilepsies (GGE) and non-acquired focal epilepsies (NAFE) (horizontal panel) in selected variant classes (vertical panels) is shown on the x-axis (log odd ratios from Likelihood Ratio Test; error bars indicate 95% confidence intervals). False-Discovery-Rate-adjusted p values are indicated with stars as follows: no star > 0·05, * < 0·05, ** < 0·005, *** < 0·0005, **** < 0·00005. NDD-Epilepsy: neurodevelopmental disorders with epilepsy. FMPR: Fragile-X Mental Retardation Protein. MGI: Mouse Genome Informatics database.