Fig. 3.

(a) SNCA is predominantly expressed in brain, as the violin plots show. All 13 brain tissues are within the top 16 GTEx tissues expressing SNCA. (b) Immunopanning data on brain cell expression from Barres Lab shows SNCA predominantly expresses in neurons and oligodendrocytes. GMSCA tags SNCA as neuronal and oligodendrocytic in the substantia nigra, putamen and hippocampus. (c) APP, genetically linked to Alzheimer, is another interesting gene found in the same module as SNCA. Barres Lab’s data confirms it is predominantly expressed in neurons and oligodendrocytes. GMSCA tags it as neuronal and oligodendrocytic. (d) UpSet plot (UpSet R package) on the genes from the predictions by GMSCA on the GTEx substantia nigra samples. SNCA and APP are found at the intersection between N (neurons) and OLG (oligodendrocytes) with 378 genes more. (e) gProfileR enrichment annotation for the secondary network module midnightblue in which we find SNCA and APP appearing together