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. 2021 Sep 9;24(10):103095. doi: 10.1016/j.isci.2021.103095

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© 2021.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Global network alterations in germ-free mice after stroke

(A) Degree distribution (Poisson regression with likelihood ratio test: different curve for each dataset, p < 0.01) and difference in total degree between naive and stroke SPF mice (Student's t test, n.s.).

(B) Degree distribution (Poisson regression with likelihood ratio test: different curve for each dataset, p < 0.001) and difference in total degree (naive – stroke) for GF mice (Student's t test, p < 0.001).

(C) Node strength distribution (Poisson regression with likelihood ratio test: different curve for each dataset, p < 0.01) and difference in total strength (naive – stroke) for SPF mice (Student's t test, p < 0.001).

(D) Node strength distribution (Poisson regression with likelihood ratio test: different curve for each dataset, p < 0.001) and difference in total strength (naive – stroke) for GF mice (Student's t test, p < 0.001).

(E) Global graph theoretical measures for naive and stroke SPF and GF mice, respectively (two-way ANOVA with FDR correction for multiple comparisons).

Data are represented as histogram (counts of mean degree/node strength values) and bar plots (mean and SD with individual data points per animal). naive/stroke: SPF n = 8/7, GF n = 15/7.