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. Author manuscript; available in PMC: 2021 Sep 29.
Published in final edited form as: FASEB J. 2020 Aug 3;34(9):12847–12859. doi: 10.1096/fj.202000713RR

Figure 7.

Figure 7

WISP1 expression in TCGA and GTEx databases. (A) Elevated level of WISP1 transcripts in patients with breast cancer. (B) Significant reduction in the overall survival rate for patients with a high level of WISP1. (C) Correlation of transcript levels among WISP1, TGFβ, Runx2, and Snail in skeletal tissues. (D) Correlation of transcript levels among WISP1, TGFβ, Runx2, and MMP9 in breast cancer tissues. (E) Proposed mechanism for load-driven suppression of tumor progression, in which knee loading upregulated vitamin D3 (calcitriol) and downregulated cholesterol and TGFβ, which downregulated WISP1, MMP9, and Snail.