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. Author manuscript; available in PMC: 2022 Mar 8.
Published in final edited form as: Biomacromolecules. 2021 Feb 8;22(3):1065–1079. doi: 10.1021/acs.biomac.0c01085

Figure 4.

Figure 4.

The effects of BMP-2 presentation on osteogenesis of MC3T3-E1 cells encapsulated in MMP-sensitive hydrogels. (a) ALP activity normalized to DNA content as a function of time. (b) Relative expression of osteogenic genes normalized to no BMP-2 condition at day one. Data are represented as the mean with standard deviation error bars (n = 3). Data were analyzed by two-way ANOVA. Statistical significance determined by student’s t-test within a condition between days indicated by $. Statistical significance on the same day as determined by one-way ANOVA indicated by # for those relative to the no BMP-2 condition and by @ for those relative to the soluble condition. One symbol indicates p < 0.05, two symbols indicate p < 0.01, and three symbols indicate p < 0.0001. NSD = Not statistically different.