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Retrosynthetic scheme for the synthesis of the PQS hapten (8), analogous to the 2-heptyl-3-hydroxy-4(1H)-quinolone (PQS) quorum sensing molecule of the pqs system from P. aeruginosa. The hapten was synthesized through a five-step synthetic pathway from 3-(4-aminophenyl)propanoic acid and methyl 3-oxodecanoate.
