Table 1.
Dansylated amino acid derivatives measured in TBI brains 24 h after TBI
| Metabolite | Average concentration injured hemisphere (pmole/mg tissue) | Average concentration contralateral hemisphere (pmole/mg tissue) | Difference in metabolite concentration | Fold change | p value |
|---|---|---|---|---|---|
| Aspartate | 1.11 E04 | 4.68 E03 | 6.42 E03 | 2.37 | 3.60E-12 |
| Ornithine | 7.48 E01 | 3.63 E01 | 3.85 E01 | 2.06 | 5.57E-05 |
| Glutamate | 1.19 E04 | 6.23 E03 | 5.72 E03 | 1.92 | 3.39E-12 |
| Citrulline | 3.07 E01 | 1.83 E01 | 1.24 E01 | 1.68 | 1.43E-09 |
| Glutamine | 3.02 E03 | 2.36 E03 | 6.61 E02 | 1.28 | 1.56E-06 |
| Serine | 1.47 E03 | 1.22 E03 | 2.55 E02 | 1.21 | 5.29E-09 |
| GABA | 1.22 E03 | 1.02 E03 | 2.03 E02 | 1.2 | 2.50E-02 |
| Isoleucine | 9.17 E01 | 7.77 E01 | 1.40 E01 | 1.18 | 2.43E-01 |
| Asparagine | 1.21 E02 | 1.08 E02 | 1.29 E01 | 1.12 | 1.40E-02 |
| Alanine | 2.30 E02 | 2.11 E02 | 1.90 E01 | 1.09 | 1.12E-01 |
| Valine | 1.04 E02 | 9.52 E01 | 8.57 E00 | 1.09 | 5.97E-01 |
| Leucine | 6.07 E01 | 6.13 E01 | -6.10 E-01 | 0.99 | 6.08E-01 |
| Arginine | 2.74 E01 | 3.19 E01 | -4.46 E00 | 0.86 | 1.63E-01 |
| Phosphoserine | 3.16 E00 | N/A | 3.16 E00 | - | - |