REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-CD45	BD	558411
Anti-CD3	BD	560770
Anti-CD16	Beckman	A33098
Anti-NKG2A	Beckman	PNA60797
Anti-CD20	BD	555624
Anti-Granzyme B	BD	561151
Anti-CXCR5	MABTech	11-9185-42
Anti-PD-1	Biolegend	329922
Anti-CD4	BD	560811
Anti-MHC-E	Biolegend	342603
Anti-HLA-DR	OZYME	307626
Anti-IFNg	BD	554702
Anti-IL-10	Biolegend	501420
Anti-IL6	BD	559331
Anti-CD8	Miltenyi	BW135/80
Anti-CD3	BD	560770
Anti-CD20	BD	560631
Anti-IgD	Southern Biotech	2030-07
Anti-CD27	BD	560609
Anti-CD107a	BD	555802
Anti-IgG	BD	555786
Anti-IgM	BD	562031
Anti-Ki67	BD	556027
Anti-CD14	BD	557154
Anti-PE microbeads	Miltenyi	130-048-801
Anti-CD20 microbeads	Miltenyi	130-091-105
Critical commercial assays
Human NK cell isolation kit	Stemcell	17955
RNeasy Mini Kit	Qiagen	205113
High-Sensitivity DNA Assay Kit	Invitrogen	Q33120
Recombinant proteins
Human IL-2	Miltenyi	130-097-746
Human IL-4	Miltenyi	130-093-917
Human IL-15	Miltenyi	130-095-760
Human IL-6	Miltenyi	130-093-931
Human GM-CSF	Miltenyi	130-093-862
Experimental models: organisms/strains
Wild-type SIVagm.sab92018	Diop OM et al., J. Virol., 2000 (https://10.1128/jvi.74.16.7538-7547.2000)	N/A
SIVmac251 isolate	Huot et al. Nat. Med. 2017 (https://doi.org/10.1038/nm.4421)	N/A
Oligonucleotides
Primers for IL-6, see STAR Methods	ACD	https://acdbio.com
Deposited data
RNA sequencing raw data	This paper and Huot et al. Nat. Med. 2021 (https://doi.org/10.1038/s41467-021-21402-1)	GSE140600
Software and algorithms
Fiji (ImageJ)	Open Source	https://imagej.net/software/fiji/
Prism	GraphPad	https://www.graphpad.com
CLC Sequence Viewer 7	Open Source	https://clc-sequence-viewer.software.informer.com
BD FACSDiva	BD	https://www.bdbiosciences.com
FlowJo	BD	https://www.flowjo.com
Other
Monkey IL6 genome references (ENSMFAG00000000229, ENSCSAG00000013925)	Ensembl	https://www.ensembl.org
Monkey IL6R genome references (ENSCSAG00000001948, ENSMFAT00000012800, ENSMFAT00000012809, ENSMFAT00000012806, ENST00000344086, ENST00000368485, ENST00000476006, ENST00000512471, ENST00000622330)	Ensembl	https://www.ensembl.org