REAGENT or RESOURCE	SOURCE	IDENTIFIER
Bacterial and Virus Strains
One Shot TOP10 Chemically Competent E. coli	Invitrogen	C404006
Chemicals, Peptides and Recombinant Proteins
Tricaine (MS-222)	Syndel	Tricaine-S
SU5402	Selleckchem	S7667
Nicotinamide (NAM)	Sigma	N0636
Sirtinol	Sigma	566321
FK-866	Cayman Chemical	13287
Doxycycline	Sigma	D9891
Cas9 protein	PNA Bio	CP01-200
T7 nuclease	New England Biolabs	M0302L
Pfusion Taq polymerase	New England Biolabs	M0535L
Critical Commercial Assays
mMESSAGE mMACHINE	Invitrogen	AM1340
MEGAshortscript Kit	ThermoFisher SCIENTIFIC	AM1354
RNeasy Mini Kit	QIAGEN	74104
Superscript VILO cDNA Synthesis Kit	Invitrogen	11754050
LightCycler 480 SYBR Green master mix	Roche	04-887-352-001
TruSeq RNA Library Prep Kit v2	Illumina	RS-122-2001
Gateway LR Clonase II Enzyme mix	ThermoFisher SCIENTIFIC	11791020
Trizol Reagent	ThermoFisher SCIENTIFIC	15596018
Deposited Data
Raw and analyzed data	This paper	GEO:GSE182113
Experimental Models: Organisms/Strains
Zebrafish hspd1 mutant strain (nbl)	ZIRC	ZL737
Zebrafish strain sirt1wcm18/wcm18	This paper	sirt1wcm18/wcm18
Zebrafish strain sirt1wcm19/wcm19	This paper	sirt1wcm19/wcm19
Zebrafish strain Tg(hspd1:d2-gfp)wcm20	This paper	Tg(hspd1:d2-gfp)wcm20
Oligonucleotides
PCR primer sequences	IDT	See Table S1
sirt1 mutant genotyping primers	IDT	See Table S1
hspd1 promoter cloning primers	IDT	See Table S1
Mouse ODC D2 fragment cloning primers	IDT	See Table S1
sirt1 gRNA for CRISPR-Cas9 mutagenesis	IDT	See Table S1
Recombinant DNA
pCR4Blunt-TOPO	ThermoFisher SCIENTIFIC	K287520
pDestTol2pA2	Addgene	http://tol2kit.genetics.utah.edu
p5E-MCS	Addgene	http://tol2kit.genetics.utah.edu
pCS2FA-transposase	Addgene	http://tol2kit.genetics.utah.edu
pME-EGFP	Addgene	http://tol2kit.genetics.utah.edu
Software and Algorithms
ImageJ	NIH	https://imagej.nih.gov/ij/
R	Cran	https://www.R-project.org/
Star V2.3	rna-star	http://code.google.com/p/rna-star/
DESeq2	Bioconductor	https://doi.org/10.18129/B9.bioc.DESeq2
Prism7	Graphpad	https://www.graphpad.com/scientific-software/prism/
GSEA	UC-SanDiego, Broad Institute	https://www.gsea-msigdb.org/gsea/