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. 2021 Sep 8;9:667624. doi: 10.3389/fcell.2021.667624

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Copyright © 2021 Sun, Xu, Li, Xia, Li, Han, Fei, Zhou and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transfection of pcDNA-MALAT1 inhibited the expression of miR-146a but promoted the expression of COX2 mRNA/protein (*p < 0.05 vs. control group). (A) Relative expression of MALAT1 was highly increased in hPASMCs transfected pcDNA-MALAT1. (B) Relative expression of miR-146a was suppressed in hPASMCs transfected with pcDNA-MALAT1. (C) Relative expression of COX2 mRNA was promoted in hPASMCs transfected with pcDNA-MALAT1. (D) Relative expression of COX protein was boosted in hPASMCs transfected with pcDNA-MALAT1. (E) Relative expression of MALAT1 was highly increased in rPASMCs transfected with pcDNA-MALAT1. (F) Relative expression of miR-146a was suppressed in rPASMCs transfected with pcDNA-MALAT1. (G) Relative expression of COX2 mRNA was promoted in rPASMCs transfected with pcDNA-MALAT1. (H) Relative expression of COX protein was boosted in rPASMCs transfected with pcDNA-MALAT1.