TABLE 1.
Demographic and clinicopathological characteristics of the participants in this study.
| Characteristics | MALAT1 Hypermethylated + miR-146a Hypomethylated (n = 42) | MALAT1 Hypermethylated + miR-146a Hypermethylated (n = 42) | MALAT1 Hypomethylated + miR-146a Hypomethylated (n = 42) | MALAT1 Hypomethylated + miR-146a Hypermethylated (n = 42) | P value |
| Age, years | 63.1 ± 5.4 | 62.6 ± 6.6 | 64.6 ± 8.3 | 62.6 ± 3.8 | 0.521 |
| Gender (male/female) | 39/3 | 37/5 | 39/3 | 40/2 | 0.666 |
| Height, cm | 167.1 ± 6.4 | 168.5 ± 6.9 | 167.3 ± 6.7 | 167.1 ± 4.3 | 0.320 |
| Weight, kg | 75.1 ± 5.5 | 76.1 ± 6.9 | 74.8 ± 6.3 | 71.1 ± 5.8 | 0.563 |
| Smoking, pack-years | 37.7 ± 6.5 | 34.3 ± 6.6 | 34.2 ± 5.5 | 36.3 ± 3.5 | 0.892 |
| Smoking, status | 0.426 | ||||
| Current Smoker | 25 (59.5) | 23 (54.8) | 25 (59.5) | 28 (66.7) | |
| Ex-Smoker | 17 (40.5) | 19 (45.2) | 17 (40.5) | 14 (33.3) | |
| GOLD stage | 0.328 | ||||
| I | 6 (14.3) | 6 (14.3) | 3 (7.2) | 3 (7.1) | |
| II | 18 (42.8) | 15 (35.7) | 20 (47.6) | 15 (35.7) | |
| III | 14 (33.4) | 16 (38.1) | 18 (42.8) | 19 (45.3) | |
| IV | 4 (9.5) | 5 (11.9) | 1 (2.4) | 5 (11.9) | |
| FVC (% of predicted value) | 96.5 ± 6.4 | 79.1 ± 7.4 | 86.1 ± 6.9 | 75.7 ± 6.5 | <0.01 |
| FEV1 (% of predicted value) | 61.2 ± 7.1 | 45.2 ± 7.1 | 55.4 ± 6.2 | 37.8 ± 3.8 | <0.01 |
| DLCO (% of predicted value) | 72.5 ± 9.1 | 58.3 ± 6.3 | 64.2 ± 7.8 | 51.1 ± 4.2 | <0.01 |