Table 5.
Polymorphic sites in ERG11 sequences.
| Species | Strains number | Resistance to fungal drugs | Gene | Base mutation sits | Amino acid substitution |
|---|---|---|---|---|---|
| C. albicans | NCU_B138 | Fluconazole | ERG11 | C368T/T394C | T123I/Y132H |
| NCU_B149 | Voriconazole, Fluconazole | ERG11 | G340T/T768C | A114S | |
| NCU_B154 | Voriconazole, Fluconazole | ERG11 | G340T/T768C | A114S | |
| C. parapsilosis | NCU_O080 | Voriconazole, Fluconazole | ERG11 | T591C | None |
| NCU_B136 | Fluconazole | ERG11 | A395T/T591C/G1193T | Y132F/R398I | |
| C. tropicalis | NCU_B128 | Voriconazole, Fluconazole | ERG11 | T225C/G264A/A395T/C461T | Y132F/S154F |
| NCU_B147 | Voriconazole, Fluconazole | ERG11 | G264A/C461T/G1362A/G1504A | S154F/D454N | |
| C. haemulonii | NCU_B011 | Voriconazole, Fluconazole | ERG11 | A395T | Y132H |