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. 2021 Aug 31;20:100141. doi: 10.1016/j.mcpro.2021.100141

Fig. 6.

Fig. 6

The role of MALAT1 in lipid metabolism contributes to its functions in promoting cell proliferation, migration, and invasion.A, cell proliferation of HCCLM3 (upper panel) and PLC (lower panel) cells with MALAT1 knockdown cultured with or without oleic acid (10 μM). The increase of cell proliferation delivered by oleic acid supplementation (relative proliferation) was calculated by dividing the absorbance of cells treated with oleic acid supplementation with the absorbance of the corresponding untreated cells. Data represent mean ± s.d. of triplicate independent experiments (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, by two-sided Student’s t test). B, matrigel invasion assay using HCCLM3 (left panel) and PLC (right panel) cells with MALAT1 knockdown cultured with or without oleic acid (10 μM). Representative images of the invaded cells are shown on the left in each panel. Data represent mean ± s.d. of triplicate independent experiments (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, by two-sided Student’s t test). C, migration assay using HCCLM3 (left panel) and PLC (right panel) cells with MALAT1 knockdown cultured with or without oleic acid (10 μM). Representative images of the migrated cells are shown on the left in each panel. The plots on the right show the cell migration distances at the indicated time points. Data represent means ± s.d. of triplicate independent experiments (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, by two-tailed student’s t test).