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The proposed molecular mechanism by which MALAT1 promotes cell proliferation and invasion through regulating lipogenesis. MALAT1 modulates the expression of genes in the AMPK signaling and unsaturated fatty acid biosynthesis pathways, thereby elevates glucose uptake and lipogenesis. The synthesized fatty acids are converted to TG for energy storage and phospholipids for cell membrane construction, which facilitates the cell proliferation and invasion of HCC cells.
