Table 1.
Distribution of clinical variables among total, high and low GGT/ALT groups
| Variables | Total (n = 558) | Low (n = 365) | High (n = 193) | P |
|---|---|---|---|---|
| Age, n (%) | 1 | |||
| ≤ 60 | 422 (75.63) | 291 (75.58) | 131 (75.72) | |
| > 60 | 136 (24.37) | 94 (24.42) | 42 (24.28) | |
| Sex, n (%) | 0.003 | |||
| Female | 84 (15.05) | 70 (18.18) | 14 (8.09) | |
| Male | 474 (84.95) | 315 (81.82) | 159 (91.91) | |
| ALT, n(%) | < 0.001 | |||
| ≤ 56 | 471 (84.41) | 299 (77.66) | 172 (99.42) | |
| > 56 | 87 (15.59) | 86 (22.34) | 1 (0.58) | |
| Albumin, n (%) | 0.057 | |||
| ≤ 40 | 268 (48.03) | 211 (54.81) | 79 (45.66) | |
| > 40 | 290 (51.97) | 174 (45.19) | 94 (54.34) | |
| TB, n (%) | 0.657 | |||
| ≤ 20 | 503 (90.14) | 349 (90.65) | 154 (89.02) | |
| > 20 | 55 (9.86) | 36 (9.35) | 19 (10.98) | |
| AFP, n (%) | 0.399 | |||
| ≤ 400 | 402 (72.04) | 282 (73.25) | 120 (69.36) | |
| > 400 | 156 (27.96) | 103 (26.75) | 53 (30.64) | |
| Cirrhosis, n (%) | 0.904 | |||
| No | 116 (20.79) | 79 (20.52) | 37 (21.39) | |
| Yes | 442 (79.21) | 306 (79.48) | 136 (78.61) | |
| Size, n (%) | < 0.001 | |||
| ≤ 5 | 360 (64.52) | 272 (70.75) | 88 (50.87) | |
| > 5 | 198 (35.48) | 113 (29.35) | 85 (49.13) | |
| Number, n (%) | 0.518 | |||
| Solitary | 468 (83.87) | 326 (84.68) | 142 (82.08) | |
| Multiple | 90 (16.13) | 59 (15.32) | 31 (17.92) | |
| Vascular invasion, n (%) | < 0.001 | |||
| No | 389 (69.71) | 286 (74.29) | 103 (59.54) | |
| Yes | 169 (30.29) | 99 (25.71) | 70 (40.46) | |
| Tumor capsule, n (%) | 0.962 | |||
| Absence | 354 (63.44) | 245 (63.64) | 109 (63.01) | |
| Presence | 204 (36.56) | 140 (36.37) | 64 (36.99) | |
| Differential, n (%) | 0.042 | |||
| Good | 184 (32.97) | 269 (69.87) | 105 (60.69) | |
| Moderate/poor | 374 (67.03) | 116 (30.13) | 68 (39.31) | |
| BCLC, n (%) | < 0.001 | |||
| A | 344 (61.65) | 260 (67.53) | 84 (48.55) | |
| B | 176 (31.54) | 108 (28.05) | 68 (39.30) | |
| C | 38 (6.81) | 17 (4.42) | 21 (12.14) | |
| GGT, n (%) | < 0.001 | |||
| ≤ 50 | 272 (48.75) | 261 (67.79) | 11 (6.36) | |
| > 50 | 286 (51.25) | 124 (32.21) | 162 (93.64) | |
| ALBI Grade, n (%) | 0.007 | |||
| A | 399 (71.51) | 289 (75.06) | 110 (63.58) | |
| B | 159 (28.50) | 96 (24.90) | 63 (36.42) |
ALT, Alanine aminotransferase; TB, Total Bilirubin; AFP, α-fetoprotein; BCLC, Barcelona Clinic Liver Cancer staging; GGT, γ-Glutamyl Transpeptidase; ALBI grade, Albumin-Bilirubin Grade