Table 3.
Multivariable Cox regression analyses showing the association of advanced liver fibrosis (defined by BARD ≥ 2) with the risk of incident heart failure, hospitalization for heart failure, all-cause mortality and cardiovascular mortality in patients with NAFLD (defined by FLI ≥ 60)
| Advanced liver fibrosis | Model 1 | Model 2 | Model 3 | Model 4 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Events (n) | HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | |
| iHF | 3039 | 1.820 | 1.698–1.950 | < 0.001 | 1.124 | 1.045–1.209 | 0.002 | 1.136 | 1.056–1.222 | < 0.001 | 1.116 | 1.037–1.201 | 0.003 |
| hHF | 1370 | 2.083 | 1.868–2.323 | < 0.001 | 1.199 | 1.069–1.344 | 0.002 | 1.219 | 1.087–1.368 | < 0.001 | 1.201 | 1.070–1.347 | 0.002 |
| All-cause mortality | 2342 | 2.104 | 1.935–2.288 | < 0.001 | 1.235 | 1.132–1.348 | < 0.001 | 1.248 | 1.143–1.362 | < 0.001 | 1.240 | 1.135–1.353 | < 0.001 |
| CV mortality | 280 | 2.140 | 1.677–2.731 | < 0.001 | 1.217 | 0.943–1.571 | 0.132 | 1.262 | 0.977–1.630 | 0.075 | 1.237 | 0.957–1.598 | 0.104 |
CI confidence interval, CV mortality cardiovascular mortality, HR hazard ratio, iHF incident heart failure, hHF incident hospitalized heart failure
Model 1: crude
Model 2: age, sex and body weight
Model 3: model 2 + alcohol drinking, smoking, regular exercise, and income status
Model 4: model 3 + hypertension, dyslipidemia, and estimated glomerular filtration rate