Table 4.
Hazard ratios and 95% confidence intervals for hospitalization for heart failure, all-cause mortality and cardiovascular mortality in patients with previous heart failure according to FLI score
Model 1 | Model 2 | Model 3 | Model 4 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Events (n) | HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | |
hHF | |||||||||||||
FLI < 20 | 495 | Ref. | Ref. | Ref. | Ref. | ||||||||
20 ≤ FLI < 60 | 677 | 1.059 | 0.943–1.189 | 0.334 | 1.123 | 0.982–1.283 | 0.090 | 1.113 | 0.973–1.272 | 0.118 | 1.040 | 0.909–1.190 | 0.567 |
FLI ≥ 60 | 250 | 1.141 | 0.980–1.328 | 0.090 | 1.469 | 1.203–1.793 | < 0.001 | 1.428 | 1.168–1.746 | < 0.001 | 1.259 | 1.027–1.543 | 0.027 |
All-cause mortality | |||||||||||||
FLI < 20 | 525 | Ref. | Ref. | Ref. | Ref. | ||||||||
20 ≤ FLI < 60 | 563 | 0.823 | 0.730–0.926 | 0.001 | 1.151 | 1.001–1.325 | 0.049 | 1.141 | 0.991–1.313 | 0.067 | 1.054 | 0.915–1.215 | 0.466 |
FLI ≥ 60 | 190 | 0.803 | 0.680–0-948 | 0.010 | 1.836 | 1.480–2.277 | < 0.001 | 1.792 | 1.441–2.228 | < 0.001 | 1.541 | 1.236–1.922 | < 0.001 |
CV mortality | |||||||||||||
FLI < 20 | 93 | Ref. | Ref. | Ref. | Ref. | ||||||||
20 ≤ FLI < 60 | 114 | 0.942 | 0.717–1.239 | 0.671 | 1.355 | 0.982–1.870 | 0.064 | 1.338 | 0.968–1.850 | 0.077 | 1.210 | 0.874–1.675 | 0.250 |
FLI ≥ 60 | 34 | 0.812 | 0.549–1.203 | 0.300 | 1.937 | 1.170–3.206 | 0.010 | 1.850 | 1.112–3.077 | 0.018 | 1.535 | 0.918–2.568 | 0.102 |
CI confidence interval, CV mortality cardiovascular mortality, HR hazard ratio, hHF hospitalized heart failure
Model 1: crude
Model 2: age, sex and body weight
Model 3: model 2 + alcohol drinking, smoking, regular exercise, and income status
Model 4: model 3 + hypertension, diabetes mellitus, dyslipidemia, and estimated glomerular filtration rate