Table 5.
Multivariable Cox regression analyses showing the association of advanced liver fibrosis (defined by BARD ≥ 2) with the risk of hospitalization for heart failure, all-cause mortality and cardiovascular mortality in patients with both NAFLD (defined by FLI ≥ 60) and previous heart failure
| Advanced liver fibrosis | Model 1 | Model 2 | Model 3 | Model 4 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Events | HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | |
| hHF | 213 | 1.456 | 1.027–2.065 | 0.035 | 1.162 | 0.811–1.665 | 0.413 | 1.127 | 0.786–1.616 | 0.517 | 1.089 | 0.758–1.565 | 0.644 |
| All-cause mortality | 169 | 1.994 | 1.267–3.138 | 0.003 | 1.615 | 1.017–2.566 | 0.042 | 1.656 | 1.038–2.639 | 0.034 | 1.597 | 1.001–2.548 | 0.049 |
| CV mortalitya | 33 | 5.525 | 1.051–29.053 | 0.044 | 5.476 | 1.031–29.088 | 0.046 | 5.787 | 1.097–30.538 | 0.039 | 5.454 | 1.047–28.400 | 0.044 |
CI confidence interval, CV mortality cardiovascular mortality, HR hazard ratio, hHF hospitalized heart failure
Model 1: crude
Model 2: age, sex and body weight
Model 3: model 2 + alcohol drinking, smoking, regular exercise, and income status
Model 4: model 3 + hypertension, dyslipidemia, and estimated glomerular filtration rate
aDue to the small number of CV mortality events, Firth’s logistic regression was performed