Table 2.
Outcome measures of patients with AF versus without AF
| Outcome variables | Pre-matched population (n = 1755) | Post-matched population (n = 814) | ||||||
|---|---|---|---|---|---|---|---|---|
| With AF (n = 550) |
Without AF (n = 1205) |
Univariable analysis | With AF (n = 407) |
Without AF (n = 407) |
Univariable analysis | |||
| Effect size (95% CI) | P-value | Effect size (95% CI) | P-value | |||||
| Primary outcome | ||||||||
| mRS at 90 d, median (IQR) | 4 (1–5) | 3 (0–5) | 0.59 (0.47–0.74) a | < 0.01 | 3 (0–5) | 3 (1–5) | 1. 16 (0.82–1.52) a | 0.29 |
| Secondary outcomes | ||||||||
| Successful recanalization after first attempt c | 267/550 (48.6) | 588/1205 (48.8) | 0.99 (0.81–1. 21) b | 0.92 | 209/407 (51.4) | 190/407 (46.7) | 1. 21 (0.92–1.59) b | 0.18 |
| Successful recanalization after final attempt c | 479/550 (87.1) | 1065/1205 (88.4) | 0.89 (0.65–1. 20) b | 0.44 | 355/407 (87.2) | 347/407 (85.3) | 1. 18 (0.79–1.76) b | 0.42 |
| Complete recanalization after final attempt d | 376/550 (68.4) | 789/1205 (65.5) | 1. 14 (0.92–1.41) b | 0. 24 | 279/407 (68.6) | 264/407 (64.9) | 1. 18 (0.88–1.58) b | 0.27 |
| mRS 0–1 at 90 d | 174/518 (33.6) | 521/1162 (44.8) | 0.62 (0.50–0.77) b | < 0.01 | 143/387 (37.0) | 143/386 (37.1) | 1.00 (0.74–1.33) b | 0.98 |
| mRS 0–2 at 90 d | 195/518 (37.6) | 565/1162 (48.6) | 0.64 (0.52–0.79) b | < 0.01 | 160/387 (41.3) | 155/386 (40.2) | 1.05 (0.79–1.40) b | 0.74 |
| mRS 0–3 at 90 d | 252/518 (48.7) | 676/1162 (58.2) | 0.68 (0.55–0.84) b | < 0.01 | 208/387 (53.8) | 192/386 (49.7) | 1. 17 (0.89–1.56) b | 0.27 |
| Safety outcomes | ||||||||
| Intra-procedural complications e | 63/550 (11.5) | 95/1205 (7.9) | 1.51 (1.08–2. 12) b | 0.02 | 43/407 (10.6) | 36/407 (8.8) | 1. 22 (0.76–1.94) b | 0.41 |
| Any ICH within 24 h | 158/516 (30.6) | 222/1163 (19.1) | 1.87 (1.48–2.37) b | < 0.01 | 106/384 (27.6) | 95/388 (24.5) | 1. 18 (0.85–1.62) b | 0.32 |
| PH2 within 24 h f | 35/516 (6.8) | 41/1163 (3.5) | 1.99 (1. 25-3. 17) b | < 0.01 | 25/384 (6.5) | 23/388 (5.9) | 1. 11 (0.62–1.98) b | 0.74 |
| Symptomatic ICH within 24 h f | 54/513 (10.5) | 70/1156 (6.1) | 1.83 (1. 26-2.65) b | < 0.01 | 36/381 (9.4) | 35/386 (9.1) | 1.05 (0.64–1.71) b | 0.86 |
| Death within 90 d | 100/518 (19.3) | 162/1162 (13.9) | 1.48 (1. 12-1.94) b | 0.01 | 63/387 (16.3) | 71/386 (18.4) | 0.86 (0.59–1. 25) b | 0.44 |
Abbreviations: AF atrial fibrillation, CI confidence interval, ICH intracranial hemorrhage, IQR interquartile range, mRS modified Rankin Scale, mTICI modified Thrombolysis in Cerebral Infarction, OR odds ratio, PH2 parenchymal hematoma type 2
Data are shown as the event number/total number (%), unless otherwise indicated
aThe common OR values were calculated using an ordinal logistic regression model and indicated the odds of improvement of 1 point on the mRS at 90 days
bThe OR values were calculated using a binary logistic regression model
cDefined as mTICI of 2b-3
dDefined as mTICI of 3
eIncluding new territorial embolization, arterial perforation, arterial dissection, vasospasm requiring treatment and in-stent thrombosis
fccording to the Heidelberg Bleeding Classification