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. 2021 Sep 28;19:296. doi: 10.1186/s12951-021-01047-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Therapeutic mechanisms of ASA6 on atherosclerosis. A Heat map of significantly up regulated and down regulated genes in aorta after ASA6 treatment (fold change ≥ 2 and P < 0.05). B KEGG pathway enrichment analysis of differentially expressed genes. The top 20 enriched pathways are shown. C Circos Plots of KEGG enrichment in lipid metabolism and macrophage polarization pathway related genes. D Relative expression levels of differentially expressed transcripts in aorta related to lipid metabolism and macrophage polarization pathway (data from A). E-G Plasma LDL, CHO and TG levels in ApoE^−/− control and ASA6 treated groups. Data represent means ± s.d. from three independent replicates. ^*P < 0.05, ^**P < 0.01, Student’s t test (E–G)