Table 2.

Cox regression analyses of all-cause mortality

		Univariate			Model 1*			Model 2†
		HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value
All patients with pro-CNP ≥median (n=928) are included
Pro-CNP (per 1 pmol/L increase)	30-day mortality	1.02	1.01 to 1.03	<0.001	1.00	0.99 to 1.01	0.89	1.00	0.99 to 1.02	0.57
	1-year mortality	1.02	1.01 to 1.03	<0.001	1.00	0.99 to 1.01	0.89	1.00	0.99 to 1.02	0.58
Females with pro-CNP ≥median (n=260) are included
Pro-CNP (per 1 pmol/L increase)	30-day mortality	1.05	1.02 to 1.07	<0.001	1.04	1.01 to 1.07	0.008	1.04	1.01 to 1.07	0.016
	1-year mortality	1.04	1.02 to 1.07	<0.001	1.03	1.01 to 1.06	0.010	1.04	1.01 to 1.06	0.007
Males with a pro-CNP ≥median (n=668) are included
Pro-CNP (per 1 pmol/L increase)	30-day mortality	1.02	1.01 to 1.03	0.001	1.00	0.98 to 1.02	0.86	1.00	0.98 to 1.02	0.92
	1-year mortality	1.02	1.01 to 1.03	<0.001	1.00	0.98 to 1.01	0.72	1.00	0.98 to 1.02	0.86

All patients with a pro-CNP ≥median of the sex-specific and age-specific reference interval are included in the analyses to test the predictive value of pro-CNP as a continuous variable (per 1 pmol/L increase).

*Multivariable model with age and plasma creatinine included as covariables.

†Multivariable model with age, plasma creatinine, pro-ANP, tertiles of peak troponins, number of vessels affected, and time from onset of symptoms to blood sample included as covariables.

ANP, atrial A-type natriuretic peptides; CNP, C-type natriuretic peptide.