Table 3.

Compounds directly target mutp53

Compound name	Mechanism	Targets	References
Hsp90 inhibitor	Hsp90 inhibitor prevents Hsp90 chaperone from binding to mutp53 and promotes mutp53 proteins degradation	R175H, L194F, R248Q, R273H, R280K, R172H (mouse)	[173]
HDAC inhibitor	HDAC inhibitor inhibits HDAC-regulated transcription and disrupts HDAC6/Hsp90/mutp53 complex	R175H, R280K, V247F/P223L	[56]
Statins	Statins inhibits the interaction between mutp53 and DNAJA1 to induce CHIP-dependent p53 degradation	V157F, R172H, R175H, Y220C, R248W, R273H, R280K	[174]
Gambogic acid	Gambogic acid increases wtp53 proteins levels, inhibits mutp53-Hsp90 complex and induces CHIP-mediated degradation	R175H, G266E, R273H, R280K	[58]
Spautin-1	Spautin-1 inhibits macroautophagy to induce mutp53 degradation via chaperone-mediated autophagy	P98S, P151H, A161T, R175C, R175D, R175H, L194F, S227K, S227R, G245C, R248L, R248W, E258K, R273H, R273L, R280K, and R282W	[99]
NSC59984	NSC59984 promotes MDM-mediated mutp53 protein degradation and stimulating p73	R175L, R175H, S241F, R273H/P309F	[175]
Disulfiram (DSF)	Disulfiram catalyzes both wtp53 and mutp53 through the 26S proteasome pathway	R273H	[176]