Table 4.
Top 5 up- and downregulated DEGs between OA, RA and NC
| Term | NC vs. OA | NC vs. RA | OA vs. RA | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Symbol | logFC | Adj.P.Val | ID | Symbol | logFC | Adj.P.Val | ID | Symbol | logFC | Adj.P.Val | |
| Up-regulated | 4613 | MYCN | 9.180080878 | 8.02E-28 | 8935 | SKAP2 | 9.553082085 | 1.26E-35 | 23,094 | SIPA1L3 | 7.79814072 | 5.46E-25 |
| 6598 | SMARCB1 | 9.03478793 | 8.02E-28 | 10,745 | PHTF1 | 9.39043259 | 1.29E-34 | 1404 | HAPLN1 | 7.87947808 | 3.69E-22 | |
| 23,365 | ARHGEF12 | 9.51514144 | 3.28E-27 | 22,925 | PLA2R1 | 7.801574317 | 1.29E-34 | 5074 | PAWR | 6.908165575 | 1.22E-21 | |
| 5137 | PDE1C | 9.117030454 | 4.96E-27 | 9488 | PIGB | 9.97554221 | 1.04E-33 | 10,100 | TSPAN2 | 5.2303578 | 4.83E-18 | |
| 8697 | CDC23 | 9.841678124 | 6.56E-27 | 9294 | S1PR2 | 9.470029664 | 1.04E-33 | 22,999 | RIMS1 | 4.725490721 | 6.50E-18 | |
| Down-regulated | 5340 | PLG | -5.068734955 | 2.10E-17 | 5208 | PFKFB2 | -7.906263354 | 5.11E-25 | 954 | ENTPD2 | -10.57701223 | 1.29E-43 |
| 7368 | UGT8 | -7.56536003 | 7.07E-17 | 9024 | BRSK2 | -6.728489168 | 2.71E-24 | 4846 | NOS3 | -9.366652871 | 3.92E-41 | |
| 3575 | IL7R | -6.966596378 | 3.51E-16 | 23,308 | ICOSLG | -7.439436875 | 8.41E-24 | 6875 | TAF4B | -9.588028779 | 2.08E-40 | |
| 1404 | HAPLN1 | -8.500030865 | 2.05E-15 | 2676 | GFRA3 | -7.481477156 | 2.29E-23 | 2395 | FXN | -9.989764717 | 6.81E-40 | |
| 22,999 | RIMS1 | -5.348208851 | 4.24E-14 | 6875 | TAF4B | -8.729849528 | 2.50E-23 | 777 | CACNA1E | -9.95687779 | 7.39E-39 | |
DEGs differentially expressed genes, OA osteoarthritis, RA rheumatoid arthritis, NC normal control, logFC log fold change