Table 5.
The joint effects of green tea consumption with DNMT3B − 149 genotypes and DNA damage level on lung cancer risk
| Variables | Drinking status | Drinking duration in years | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Drinkers | Non-drinkers | > 10 | ≤ 10 | 0 | ||||||
| CA/CN | OR (95% CI)a | CA/CN | OR (95% CI)a | CA/CN | OR (95% CI)a | CA/CN | OR (95% CI)a | CA/CN | OR (95% CI)a | |
| DNMT3B -149 genotypes | ||||||||||
| TT | 42/121 | 1.47 (0.65–3.31) | 141/224 | 2.15 (0.96–4.79) | 19/58 | 0.94 (0.38–2.33) | 23/63 | 1.12 (0.45–2.77) | 141/224 | 1.50 (0.62–3.62) |
| CT | 2/9 | 1.00 (Ref.) | 5/26 | 1.22 (0.48–3.12) | 2/5 | 1.00 (Ref.) | 0/4 | – | 5/26 | 0.86 (0.32–2.33) |
| Test for interaction | χ2 = 0.13 (1 df); p = 0.72 | χ2 = 3.05 (2 df); p = 0.22 | ||||||||
| DNA damage level | ||||||||||
| High | 26/40 | 2.26 (1.41–3.63)** | 80/89 | 2.75 (1.78–4.25)** | 13/20 | 2.64 (1.82–3.83)** | 13/20 | 2.82 (1.97–4.03)** | 80/89 | 3.31 (2.55–4.30)** |
| Moderate | 10/42 | 1.16 (0.68–1.96) | 29/83 | 1.77 (1.12–2.80)* | 5/23 | 1.29 (0.82–2.05) | 5/19 | 1.51 (0.94–2.42) | 29/83 | 2.13 (1.38–3.29)* |
| Low | 8/48 | 1.00 (Ref.) | 37/78 | 1.80 (1.15–2.82)* | 3/20 | 1.00 (Ref.) | 5/28 | 1.39 (0.88–2.17) | 37/78 | 2.17 (1.28–3.68)* |
| Test for interaction | χ2 = 2.25 (2 df); p = 0.32 | χ2 = 2.61 (4 df); p = 0.63 | ||||||||
Abbreviation: CA/CN case numbers/control numbers; OR odds ratio; CI confidence interval; Ref. reference; df degree of freedom
aData were matched by age and gender, calculated by backward stepwise log-linear regression, and adjusted for pack-years of smoked, and exposure to cooking fumes
*0.01 < p < 0.05, ***p < 0.001