Table 4.

Univariate and Multivariate Analysis of Prognostic Factors for LPFS and OS

LPFS					OS
Characteristics	Median LPFS (months)	UVA P value	MVA P value	MVA HR	Characteristics	Median OS (months)	UVA P value	MVA P value	MVA HR
KPS at time of QS					KPS at time of QS
≤ 70 (reference)	3.8 [3.3–4.4]	<0.001	0.001	0.54 [0.38–0.77]	≤ 70 (reference)	4.5 [3.4–5.5]	<0.001	0.001	0.52 [0.35–0.78]
> 70	7.0 [5.9–8.1]				> 70	8.2 [5.4–11.0]
>2 years intervals					Histology
No (reference)	4.3 [3.4–5.2]	0.026	0.104	0.74 [0.51–1.07]	SCC (reference)	6.0 [5.1–6.9]	0.019	0.005	0.51 [0.32–0.82]
Yes	5.9 [4.9–6.9]				Others	11.3 [3.2–19.5]
RT modalities					Organ dysfunction at QS
Photon (reference)	3.5 [2.8–4.2]	0.003	0.021	0.67 [0.45–0.94]	No (reference)	7.6 [5.4–9.8]	0.019	0.57	1.12 [0.76–1.67]
Proton	6.2 [5.3–7.2]				Yes	5.8 [4.7–6.8]
QS cycles					RT modalities
1 or 2 (reference)	2.3 [1.4–3.2]	<0.001	0.002	0.56 [0.38–0.81]	Photon (reference)	5.4 [4.0–6.8]	0.001	0.031	0.65 [0.44–0.96]
3 or 4	6.5 [5.5–7.4]				Proton	8.3 [5.3–11.3]
Palliation achieved					Concurrent therapy systemic
No (reference)	2.8 [1.3–4.3]	<0.001	<0.001	0.41 [0.28–0.62]	No (reference)	5.3 [3.8–6.9]	0.033	0.136	0.74 [0.50–1.10]
Yes	6.2 [5.4–6.9]				Yes	7.6 [5.9–9.3]
Age	NS				QS cycles
Gender	NS				1 or 2 (reference)	3.9 [3.1–4.6]	<0.001	0.002	0.53 [0.35–0.79]
Histology	NS				3 or 4	9.6 [6.2–13.1]
Salvage before QS Surgery	NS				Palliation achieved
Organ dysfunction	NS				No (reference)	4.3 [3.4–5.1]	<0.001	0.001	0.50 [0.33–0.77]
Concurrent treatment systemic	NS				Yes	8.3 [5.4–11.1]
					Age	NS
					Gender	NS
					Salvage Surgery before	NS
					QS
					>2 years intervals	NS