Table 2.

Diagnosis of overlap syndromes

	Laboratory features	Histologic findings
AIH/PBC	ANA or SMA Hypergammaglobulinemia Serum IgG level increased Marked serum AST/ALT abnormalities ALP or GGT > ULN AMA positive	Interface hepatitis Lymphocytic portal infiltrate Portal plasma cells Destructive cholangitis
AIH/PBC (Paris Criteria)	AIH features (2 of 3): Serum ALT >  = fivefold ULN Serum IgG >  = twofold ULN or SMA present Interface hepatitis PBC features (2 of 3): Serum ALP >  = twofold ULN or GGT >  = fivefold ULN AMA positive Florid duct lesions	Interface hepatitis (moderate to severe) Destructive cholangitis