Chang 2008.

Study characteristics
Methods	RCT; 2 groups, parallel design
Participants	22 patients with acute myelogenous leukaemia, due to commence chemotherapy
Interventions	Exercise: walking exercise programme during inpatient CT, 12 minutes of supervised walking on 5 days/week for 3 weeks. Aimed to reach a target intensity of resting heart rate plus 30. Control: attention control, no additional intervention specific to fatigue
Outcomes	Fatigue Walk distance Symptom distress Mood (including anxiety and depression)
Notes	Methodological quality score: 2 Main purpose of exercise: to reduce fatigue
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"randomized" but method not stated
Allocation concealment (selection bias)	Unclear risk	Allocation not stated
Blinding of outcome assessment (detection bias) All outcomes	High risk	Blinding not done
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants were accounted for
Selective reporting (reporting bias)	Low risk	Fatigue outcome reported