Courneya 2007a.

Study characteristics
Methods	RCT; 3 groups, stratified by treatment centre and chemotherapy protocol
Participants	242 women with breast cancer initiating chemotherapy
Interventions	Aerobic exercise: supervised 3 times/week during chemotherapy. Resistance exercise: supervised 3 times/week during chemotherapy. Control: usual care
Outcomes	Quality of life Fatigue Anxiety Depression Self esteem Physical fitness Body composition Chemotherapy completion rate Lymphoedema
Notes	Methodological quality score: 2 Main purpose of exercise: to improve quality of life
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"randomly assigned...using a computer generated program"
Allocation concealment (selection bias)	Low risk	"The allocation sequence was...concealed from the project directors at each site who assigned participants to groups"
Blinding of outcome assessment (detection bias) All outcomes	High risk	Blinding not done
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants were accounted for
Selective reporting (reporting bias)	Low risk	Fatigue outcome reported