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. 2021 Jan 22;38(5):2088–2103. doi: 10.1093/molbev/msab010

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Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution 2021.

This work is written by US Government employees and is in the public domain in the US.

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Fig. 7. — Tyrosine and/or phenylalanine distinguish positive-testing cPrDs from negative-testing cPrDs. (A) Comparison of amino acid frequency in cPrDs that tested positive in both Congo red and Sup35-based yeast-assay (CR+/YPR+), and ones that tested negative in both experimental assays (CR−/YPR−). Tyrosine (Y) content of the CR+/YPR+ cPrDs were higher than the CR−/YPR− cPrDs in general. The CR+/YPR+ cPrD with no tyrosine (lowest datapoint in distribution of Y) is the same with highest phenylalanine (F) frequency (highest data point in distribution of F). (B) Frequencies of tyrosine and phenylalanine in archaeal cPrDs, yeast, and bacterial PrDs. CR+/YPR+ cPrDs as well as yeast PrDs contain significantly higher Y/F than CR−/YPR− cPrDs. The Y/F frequency distribution in bacterial PrDs is also similar to that in CR+/YPR+ cPrDs and yeast PrDs. Since the bacterial group contained PrDs of only the two experimentally confirmed prions (Rho and SSB), no statistics were performed to compare the group with other ones.