Table 5.
Associations of AD pathology and common age-related brain pathologies and global cognition with and without MIND diet score
| Model | Predictors | β-estimate (SE) | P-value | Adjusted R2, % |
|---|---|---|---|---|
| A | AD pathology | −0.595 (0.067) | <0.001 | 39.3 |
| Arteriolosclerosis, moderate–severe | −0.131 (0.082) | 0.110 | ||
| Cerebral amyloid angiopathy | −0.121 (0.09) | 0.180 | ||
| Macroinfarcts | −0.118 (0.076) | 0.122 | ||
| Microinfarcts | −0.073 (0.078) | 0.346 | ||
| Cerebral atherosclerosis, moderate–severe | −0.044 (0.086) | 0.608 | ||
| Lewy Bodies | −0.266 (0.083) | 0.001 | ||
| Hippocampal sclerosis | −0.735 (0.128) | <0.001 | ||
| TDP-43 pathology in amygdala and beyond | −0.045 (0.075) | 0.552 | ||
| B | MIND diet score | 0.103 (0.037) | 0.005 | 40.1 |
| AD pathology | −0.594 0.066 | <0.001 | ||
| Arteriolosclerosis, moderate–severe | −0.141 (0.082) | 0.084 | ||
| Cerebral amyloid angiopathy | −0.108 (0.09) | 0.229 | ||
| Macroinfarcts | −0.119 (0.076) | 0.116 | ||
| Microinfarcts | −0.086 (0.077) | 0.268 | ||
| Cerebral atherosclerosis, moderate–severe | −0.042 0.086 | 0.621 | ||
| Lewy Bodies | −0.264 (0.082) | 0.001 | ||
| Hippocampal sclerosis | −0.704 (0.128) | <0.001 | ||
| TDP-43 pathology in amygdala and beyond | −0.044 (0.074) | 0.557 |
Each model (A-B) is a separate linear regression model adjusted for the predictors (as shown in table) and age at death, sex, APOE4, education, total energy intake, and late-life cognitive activities (not shown). β-estimate for MIND diet score is for 1 standard deviation (SD=1.42) increase.