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. 2021 Sep 27;28(1):2011–2023. doi: 10.1080/10717544.2021.1981493

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Biocompatibility evaluation of Betoptic and MIDFDS. (a,b) Percent cell viability of each formulation after different exposure times and administration dosages (n = 3, mean ± SD). (c,d) Hemolysis percentage of the BH-PBS, Betoptic, and MIDFDS. The dashed line in (d) indicates 5% hemolysis. (e) The hemolysis of each test group after 4 h of incubation with erythrocytes. (f) Ocular irritation scores from rabbits (single and multiple administrations, n = 3). (g) Ocular tissues were stained with hemoxylin and eosin (H&E) following chronic application in the saline group, BH solution group, Betoptic group, and MIDFDS group (magnification 200×).